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Potential Role of the Gut Microbiome in Als a Systematic Review

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doi: ten.3390/microorganisms9050977.

Systematic Review: The Gut Microbiome and Its Potential Clinical Awarding in Inflammatory Bowel Disease

Affiliations

  • PMID: 33946482
  • PMCID: PMC8147118
  • DOI: 10.3390/microorganisms9050977

Complimentary PMC article

Review

Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease

Laila Aldars-García  et al. Microorganisms. .

Free PMC article

Abstract

Inflammatory bowel affliction (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract. It is well established that the gut microbiome has a profound impact on IBD pathogenesis. Our aim was to systematically review the literature on the IBD gut microbiome and its usefulness to provide microbiome-based biomarkers. A systematic search of the online bibliographic database PubMed from inception to August 2020 with screening in accord with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. I-hundred and forty-four papers were eligible for inclusion. There was a wide heterogeneity in microbiome analysis methods or experimental pattern. The IBD intestinal microbiome was mostly characterized by reduced species richness and diverseness, and lower temporal stability, while changes in the gut microbiome seemed to play a pivotal role in determining the onset of IBD. Multiple studies accept identified certain microbial taxa that are enriched or depleted in IBD, including leaner, fungi, viruses, and archaea. The two primary features in this sense are the decrease in beneficial leaner and the increase in pathogenic bacteria. Significant differences were also present between remission and relapse IBD status. Shifts in gut microbial community composition and abundance take proven to be valuable equally diagnostic biomarkers. The gut microbiome plays a major function in IBD, still studies demand to go from casualty to causality. Longitudinal designs including newly diagnosed handling-naïve patients are needed to provide insights into the function of microbes in the onset of intestinal inflammation. A better understanding of the human gut microbiome could provide innovative targets for diagnosis, prognosis, treatment and fifty-fifty cure of this relevant disease.

Keywords: Crohn's disease; biomarkers; gut microbiome; inflammatory bowel disease; ulcerative colitis.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential disharmonize of interest.

Figures

Figure 1
Effigy 1

Gut microbiota disturbance in inflammatory bowel disease compared to good for you individuals. Upwardly arrow indicates increase and downward pointer decrease.

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